Allylic C–H Alkynylation via Copper-Photocatalyzed Cross-Dehydrogenative Coupling

Published as part of the Bürgenstock Special Section 2019 Future Stars in Organic Chemistry

Abstract

An efficient, novel photocatalyzed allylic-alkynylation methodology via copper-based cross-dehydrogenative coupling (CDC) is described. Different types of 1,4-enyne compounds were synthesized in one step at room temperature using copper(I) terpyridyl complex as photocatalyst/initiator. This procedure is an improvement and to some extent complementary to previously reported thermal CDC methods. Preliminary investigations on the reaction mechanism are also presented.

Key words

C–C bond - copper catalyst - C–H functionalization - photocatalyst - allylic-alkynylation - 1,4-enyne

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